The Nobel Prize in Physiology or Medicine in 2021 was awarded for the discovery of receptors for temperature and touch

David Julius and Ardem Patapoutian were awarded the Nobel Prize in Physiology or Medicine in 2021. Their discoveries were focused on TRP-ion channels, the receptors responsible for heat and cold, and PIEZO-ion channels, the receptors for touch, which are also involved in sensing body position. The signal activation of ion channels that will subsequently be perceived by the brain makes these receptors vital for our survival. The study of ion channels, "sensors" of physiological state, helps to better understand the mechanisms responsible for pain, the transmission of ...

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THE RESULTS OF CHRONOS19 STUDY IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES AND COVID-19 IN RUSSIA WERE PRESENTED AT 2021 ESMO ANNUAL MEETING

This year's meeting of the European Society for Medical Oncology (ESMO) took place online on September 16-21. In frames of the scientific program, a poster on the treatment outcomes and antibody immunity to SARS-CoV-2 in patients with hematological malignancies was presented by CHRONOS19 investigators. A full abstract can be found here: https://oncologypro.esmo.org/meeting-resources/esmo-congress-2021/treatment-outcomes-and-antibody-immunity-to-sars-cov-2-in-patients-with-hematological-malignancies

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ASCO’s Clinical Cancer Advances 2021 Report

ASCO’s Clinical Cancer Advances annual report highlights current trends in the field and identifies cancer research priorities that have great potential to advance progress against cancer. The 16th edition of the annual report was developed by a 26-member editorial board of experts. The editors reviewed scientific literature published in peer-reviewed journals or presented at major medical conferences, primarily from October 2019 to September 2020, selected advances that improve meaningful patient outcomes and have a strong scientific impact, and proposed priority areas ...

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CHRONOS19 WILL BE PRESENTED AT THE EHA 2021 VIRTUAL CONGRESS

The results of the subgroup analysis of the CHRONOS19 registry in patients with acute leukemia and COVID-19 will be presented orally by the study PI Olga Gavrilina, MD, PhD, at the upcoming in June annual congress of the European Hematology Association (EHA) during the special session on the SARS-CoV-2 infection “COVID-19 impact on hematology: How it started - How it’s going”. Patients with acute leukemia are at high risk of COVID-19 severe and lethal course. Intensive chemotherapy and immunosuppression in these patients are the possible causes of high ...

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Bright scientific events in oncology in 2020

Author: Alexey Tikhonov 2020 was marked by a large number of striking events in the oncology field, and in this material, I would like to highlight a number of studies that, in my opinion, can both bring us closer to a more detailed understanding of the tumor biology, and may change approaches to the diagnosis and treatment of cancer in the future. Due to the pandemic, most of the largest oncology conferences were held online, and this undoubted advantage made it possible to immediately recognize and evaluate the presented studies. In April 2020, at the Annual ...

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CHRONOS19: INTERIM ANALYSIS OF THE OBSERVATIONAL STUDY OF COVID-19 IN PATIENTS WITH BLOOD DISEASES

НАБЛЮДАТЕЛЬНОЕ ИССЛЕДОВАНИЕ У ПАЦИЕНТОВ С ЗАБОЛЕВАНИЯМИ СИСТЕМЫ КРОВИ И COVID-19 В РОССИИ
The emergence of a new infectious disease COVID-19 led to the extensive research of not only the coronavirus itself, but also the course of this disease in different patient populations. This is especially true for patients with a high risk of severe disease and mortality, in particular, those suffering from oncologic and hematologic diseases. In order to understand how COVID-19 develops in patients with hematologic (blood) diseases, a multicenter study CHRONOS19 was launched in June 2020 among patients with COVID-19 and hematologic diseases in Russia. The study was ...

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CHRONOS19 STUDY RECOGNIZED WITH THE AMERICAN SOCIETY OF HEMATOLOGY AWARD

The interim results of the observational study "Registry of Patients with Hematologic Disease and COVID-19 in Russia" will be presented at the 62nd annual meeting of the American Society of Hematology (ASH), which will be held on December 5-8 in a virtual format. A poster presentation is included in Session: 904. Outcomes Research — Non-Malignant Conditions. The research was recognized with the Abstract Achievement Award, which supports select trainees with high-achieving annual meeting abstracts who are chosen to present their work at the ASH annual meeting. The ...

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RAKFOND AT THE RUSSIAN ONCOLOGY CONGRESS

The XXIV Russian Oncology Congress opened on November 11, 2020, in a virtual format with a joint session of the Russian Society of Clinical Oncology (RUSSCO) and RakFond, dedicated to academic research that has changed clinical practice. During the session, leading experts in oncology and hematology from Russia and the United States discussed the role of research initiated by scientists and physicians in the advancement of oncology, opportunities and limitations, barriers in implementation, and steps towards conducting their own research projects. One-hundred and ...

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PLATINUM-BASED CHEMOTHERAPY IN TREATMENT OF PATIENTS WITH PLATINUM-RESISTANT RECURRENT OVARIAN CANCER

Ovarian cancer is one of the most sensitive tumors to chemotherapy - in most cases it is possible to achieve complete tumor regression affected by modern drug treatment. Unfortunately, despite these successes, a large number of patients have developing relapses after the initial treatment, which entails the need for repeated chemotherapy. In recurrent ovarian cancer, current standards of therapy suggest treatment depending on the time elapsed since the completion of platinum-containing chemotherapy. In cases when less than 6 months have passed since the end of the ...

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Annual cancer progress report issued by the American association for cancer research

Turning science into lifesaving care The American Association for Cancer Research (AACR) released its annual Cancer Progress Report, which highlights advances over the past year in the prevention, detection, diagnosis, and treatment of cancer.  Below is a brief summary of this report. Cancer in 2020 In the United States, the overall cancer death rate has been steadily decreasing since the 1990s, with the reductions by 29 percent from 1991 to 2017 translating into more than 2.9 million cancer deaths avoided. The decline in the overall cancer death rate is being ...

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